Compare Acetaminophen vs Aspirin head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Acetaminophen rated 6.9/10 vs Aspirin rated 8.3/10 in overall patient satisfaction. Compare Acetaminophen vs Ibuprofen head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Acetaminophen rated 6.9/10 vs Ibuprofen rated 7.6/10 in overall patient satisfaction. Compare Acetaminophen vs Paracetamol head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Acetaminophen rated 6.9/10 vs Paracetamol rated 5.6/10 in overall patient satisfaction. Acetaminophen vs Ibuprofen comparison. Acetaminophen (a.k.a paracetamol) and Ibuprofen are the most widely used over-the-counter medications for relief from pain and fever. The primary difference between the two is that ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and can be used. Acetaminophen vs Aspirin comparison. Acetaminophen and Aspirin are analgesics—painkillers—with comparable efficacy, but because of its anti-inflammatory properties, aspirin can be more effective when dealing with inflammation. Acetaminophen can be given to children in limited doses, but aspir. Acetaminophen vs. ibuprofen Acetaminophen belongs to a class of drugs called analgesics. Ibuprofen belongs to the drug class called nonsteroidal anti-inflammatory drugs (NSAIDs).